Moreover, to further verify whether these genes were highly expressed in RA, the expression of EGFR and VEGFA were examined by Western blot in RA synovial tissue and normal synovial tissues, and the results showed that the expression levels of VEGFA and EGFR in the synovial tissue of RA were significantly increased (P<0.05). This evidence concerns the gene EGFR and rheumatoid arthritis.