Taken above, using bioinformatics tools and tissue sample verification, we have identified two candidate genes and pathways, and these findings may significantly improve our understanding of the causes and potential molecular events of RA, and the hub genes VEGFA and EGFR maybe have a crucial function in the pathogenesis of RA and could be used as potential biological and therapeutic indicators of RA. This evidence concerns the gene EGFR and rheumatoid arthritis.