SPP1 and neoplasm: Based on the heatmap of genes defining these clusters (Figure 3C), it was apparent that the clustering was influenced largely by genes that define mammary cell lineages or states such as Spp1, Ltf, Acta2, Lalba, Wap, Prlr, Areg and Col1a2. Accordingly, the number of tumor cells that were assigned into clusters with normal cells of a particular cell state could be determined in detail (Figure 3D).