For example, prompted by the actress Angelina Jolie who decided to undergo mastectomy upon genetic testing for the BRCA1 gene, there was a surge in referrals related to breast cancer family history, demand for BRCA1/2 testing, and enquiries about mastectomy—subsequently described as the Angelina Jolie effect (Evans et al. 2014). This evidence concerns the gene BRCA1 and breast cancer.