Recent literature reported that the transcription upregulation of RIPK3 and MLKL were controlled by SP1, STAT1, or CDK9 in various cancer cell lines60–62 and during hepatitis.63 JAK/STAT signaling pathway has been shown to play dynamic and important roles during muscle regeneration.64–67 It is possible that these transcriptional regulations of necroptosis factors may be shared in necroptotic myofibers after CTX-induced injury. The gene discussed is SP1; the disease is Hepatitis.