LEP and breast cancer: We also report that FAM83H-AS1 over-expression in TCGA breast cancer samples is associated with down-regulation of migration and cell death-related transcripts, like FGF4, FGF21, LEP, CLDN17, TP53, BAX and TNFRSF11B. Accordingly, we also found that FAM83H-AS1 knockdown significantly deregulates migration and apoptosis-related genes, such as TP63 and CLND1. Transwell migration assays showed that indeed, cellular migration increases after FAM83H-AS1 silencing.