As ligands of peroxisome proliferators-activated receptors (PPAR), AEA, and eicosanoids both activate PPARα, PPARβ/δ, and PPARγ, which bind to peroxisome proliferator hormone response elements (PPREs) of SNAILs, ZEBs or TWISTs to regulate their expression and control tumor metastasis [45–52]. This evidence concerns the gene PPARA and neoplasm.