Glycolysis blockade with 2- DG or 3-BrPA reversed NAD(P)H:quinone oxidoreductase-1 (NQO1)-induced EMT by inhibiting vimentin, Snail, Slug and Twist, and up-regulating E-cadherin, leading to attenuated NQO1-induced glycolysis and metastasis in breast cancer cells [111]. The gene discussed is NQO1; the disease is breast carcinoma.