ELF3 and gallbladder cancer: The altered genes include TP53, ELF3, ERBB3, CTNNB1, ARID2, CDNK2A, STK11, SMAD4, ARID1A, EHF, KRAS, NFE2L2, PIK3CA, and PSIP1. We further identify a class of mismatch-repair-deficient gallbladder cancers with elevated mutation rates which are likely candidates for immunotherapy.