In these studies a clinically relevant model of blast crisis chronic myelogenous leukemia (BC-CML) created by co-transducing H60-expressing mouse bone marrow (BM) with retroviruses that express cDNAs encoding the human bcr-abl and NUP98/HOXA9 translocations was used18,22. The gene discussed is NUP98; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.