Previous proteomic analyses using MLN4924 and recombinant NEDD8 proteins have identified many direct and indirect Neddylation-targets important for cancer cell tumorigenesis, proliferation, migration and drug resistance40–42; however our data showed that ERRβ is a key mediator of the anti-proliferative and anti-migratory function of MLN4924 as ERRβ silencing can overcome its ability to induce the expression of key anti-proliferative and anti-migratory genes, such as p21Waf1/Cip1 and E-cadherin. The gene discussed is CDKN1A; the disease is cancer.