Thus, whilst a region-wise quantification of TSPO showed an upregulation of the protein in the hippocampus in both Alzheimer’s disease and MCI patients compared to controls, a voxel-wise analysis of the exact same images limited this upregulation to the lateral part of the hippocampus and only in the Alzheimer’s disease patients [70]. Here, TSPO is linked to early-onset autosomal dominant Alzheimer disease.