In 3xTg-AD mice, we showed that, in all hippocampal subregions, the upregulation of TSPO occurs before the presence of amyloid deposits as detected by the [125I]CLINDE and [125I]DRM106 bindings, respectively, supporting the idea of TSPO’s early role in with respect to Alzheimer’s disease associated brain lesions [101]. The gene discussed is TSPO; the disease is amyloidosis.