TERT and breast cancer: TERT promoter mutations (C228T and C250T) have been previously detected in DNA from urinary exfoliated cells (cellDNA) collected prior to diagnosis and during post-surgical follow-up, with sensitivities and specificities varying from 52% to 82% and from 83% to 99%, respectively, in patients with incident or early BC and from 42% to 74% and 73% to 93%, respectively, in patients with recurrent BC [48,54,72,73,75,77].