The importance of hypothalamic AMPK in the regulation of different homeostatic processes has been highlighted by previous reports showing that AMPK is expressed in key hypothalamic nuclei, is regulated by fasting, increases feeding, plays an important role in central (hypothalamic) sensing of hypoglycemia and is regulated by different hormones and neurotransmitters, including ghrelin [6,27]. The gene discussed is GHRL; the disease is Hypoglycemia.