TEK and Sepsis: We (Thamm et al., 2018) and others (Sung et al., 2011; Findley et al., 2007) have shown that global blockade of MMP activity is sufficient to prevent Tie2 cleavage and thereby vascular leakage in vitro and to improve pulmonary vascular leakage and ultimately, survival in a rat sepsis model in vivo (Steinberg et al., 2003).