APP and Alzheimer disease: To overcome these drawbacks of APP overexpression, a new generation of mouse models of sporadic AD has been developed by the Saido laboratory [13] using a knock-in strategy to introduce the Swedish mutation, which increases all Aß species, into the APP gene, together with either the Beyreuther/Iberian mutation or the Beyreuther/Iberian plus the Arctic mutation [13, 14].