OTX1 and metastatic malignant neoplasm in the lymph nodes: The expression level of OTX1 in LSCC was significantly correlated with lymph node metastasis and smoking history (all P < 0.05), while there were no significant correlations between the OTX1 expression and age, sex, alcohol consumption history, T classification, histological grade, or primary location in patients with LSCC (all P > 0.05) (Table 1).