We report on a 35-year-old female patient with neutropenia, inflammatory bowel disease, massive splenomegaly and thrombocytopenia after 26 years of granulocyte-colony stimulating factor (G-CSF) treatment and a severe wound healing defect after abdominal surgery who showed remarkable improvement of wound healing and neutrophil count and function upon treatment with empagliflozin. The gene discussed is CSF3; the disease is Decreased total neutrophil count.