ESR1 and neoplasm: Patients with the following characteristics have been reported to have a high risk for LRR: young age (≤ 35 or < 45 or ≤ 50 years), inner-quadrant tumor location, histological grade III, ER- or PR-negative, triple-negative histology, presence of LVI, extensive intra-ductal component, extracapsular extension, high positive nodal ratio (> 15% or > 25%) and close surgical margin.