Recently, it has been identified that mutation in non-complement genes such as diacylglycerol kinase epsilon (DGKE) [5, 6], thrombomodulin (THBD) [6, 7], inverted formin 2 (INF2) [7] and methylmalonic aciduria and homocystinuria cobalamin C (cbLC) type (MMACHC) can also trigger aHUS [6, 7]. Here, DGKE is linked to homocystinuria.