TNF and COVID-19: Indeed, recent studies argue for an increased systemic inflammatory reaction in patients with severe SARS-CoV-2 infection: circulating concentrations of proinflammatory cytokines such as IL-6, TNF-α, MCP1, MIP1α, and IP10 are increased in COVID-19 patients on the intensive care unit (ICU) when compared to those who do not need ICU admission.1