Circulatory renin was elevated in PCOS (665 ± 22 vs 600 ± 23 RFU, PCOS vs control, p < 0.05) and angiotensinogen was low in PCOS (5368 ± 213 vs 6394 ± 383 RFU, PCOS vs control, p < 0.05), indicating overactivity of the RAS system in PCOS (Fig. 1). Here, AGT is linked to polycystic ovary syndrome.