ALB and Cirrhosis: In the Pilot-PRECIOSA study [53••], conducted on 18 non-infected patients with cirrhosis and severe circulatory dysfunction, the high albumin dose (1.5 g/kg b.w. per week) showed a significant effect on the plasma levels of IL-6, a paradigmatic proinflammatory cytokine, compared to patients treated with the low albumin dose (1 g/kg b.w every two weeks).