ALB and alcoholic hepatitis: In cases of severe alcoholic hepatitis, a condition characterized by significant oxidative and non-oxidative damage to the albumin molecule [68], it has been shown that HNA2, which includes all albumin isoforms with irreversible oxidation of the Cys34 residue, promotes neutrophils [69] and platelet activation through a CD36 mediated mechanism [70], leading to the release of proinflammatory and prooxidant mediators.