By comparing the diagnostic performance between the CAP-based LSM algorithm and the ALT-based LSM algorithm, we found that 112 (33.94%) patients had no significant fibrosis or a correct diagnosis of severe liver fibrosis/cirrhosis, 151 (45.76%) patients had an ambiguous diagnosis, and 67 (20.30%) patients had a misdiagnosis based on the ALT algorithm. The gene discussed is GPT; the disease is fibrosis.