When we next performed ultrastructural analysis between SIRT3 WT and KO lungs after infection, the TEM data showed that SIRT3-deficient lungs had a marked accumulation of damaged mitochondria, as represented by swollen and disrupted cristae, when compared with SIRT3 WT mice at 5 dpi of Mabc-R infection (Figure 2(c)). This evidence concerns the gene SIRT3 and infection.