We then compared predicted viral MHC-presented epitopes with self-peptides presented in normal tissue on 84 HLA alleles across the entire human proteome as listed in the UniProt database, prioritizing antigens that are most dissimilar from self-peptides based on: (1) higher predicted safety based on decreased likelihood of inducing autoimmunity due to cross-reactivity with similar self-peptides presented on MHC; and (2) higher immunogenicity of dissimilar peptides based on an expected greater repertoire of antigen-specific T cells resulting from a lower degree of negative thymic selection. The gene discussed is HLA-C; the disease is Autoimmunity.