The variant in VDR rs59128934 (allele G) was associated with risk to vitamin D insufficiency (OR 2.07; 95% CI 1.28–3.34; p = 0.002) as well as to deficiency (OR 1.78; 95% CI 1.12–2.83; p = 0.014), when compared to controls, ≥ 30 ng/mL and ≥ 20 ng/mL, respectively. This evidence concerns the gene VDR and vitamin D deficiency.