While positive associations were found for 3 SNVs in VDR (rs59128934, rs7965274 and rs2853564), 2 SNVs in CYP24A1 (rs56229249 and rs34043203) and 2 in CYP2R1 (rs12794714 and rs10500804), indicating that the presence of such variations increase risk to vitamin D insufficiency. The gene discussed is CYP2R1; the disease is vitamin D deficiency.