GPT and obesity due to melanocortin 4 receptor deficiency: We explored lipotoxicity in the obesity group in patients with a high risk of β-cell damage with RIAO values > 3.35 μg/ml: higher triglycerides [155 (IQ 104) vs 107 (IQ 83), p = 0.041]; lower HDL cholesterol- [37.5 (IQ 9) vs 45.2 (IQ 14), p <0.001] and higher ALT [31.6 (IQ 14) vs 19.6 (IQ 8), p = 0.002] (Fig 8).