The diagnosis of T2DM is often made late, when 60% of the pancreas is destroyed and when β-cell damage is evident; targeting the challenge to identify the metabolically unhealthy children with obesity, using a set of 22 cardiometabolic risk factors such central obesity, waist circumference, relative fat distribution, overall body fatness, signs of insulin resistance, measures of blood pressure, triacylglycerols, HDL-cholesterol, insulin, C-peptide, HOMA, ALT, uric acid, microalbuminuria and plasma glucose among others [5,6]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.