A growing body of evidence supports that inflammatory cytokines such as TNF-α, TGF-β1, and IL-6, as well as inflammasome-related factors such as IL-1β, IL-18, play a key role in the progression of NASH (Dela Pena et al. 2005; Henao-Mejia et al. 2012; Seki et al. 2007; Wieckowska et al. 2008). The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.