There is current ample evidence that the presence of adenomyosis is associated with the dysregulation of a large number of implantation-associated factors (HOXA10, LIF, MMP2, IL-6, cytochrome 450, and RCAS1), immune factors, pro-inflammatory mediators (IL-1β, CRH), markers of apoptosis and proliferation, and mediators of oxidative stress, leading to low uterine receptivity (Campo et al., 2012, Vannuccini et al., 2017). This evidence concerns the gene LIF and adenomyosis.