MMP2 and adenomyosis: There is current ample evidence that the presence of adenomyosis is associated with the dysregulation of a large number of implantation-associated factors (HOXA10, LIF, MMP2, IL-6, cytochrome 450, and RCAS1), immune factors, pro-inflammatory mediators (IL-1β, CRH), markers of apoptosis and proliferation, and mediators of oxidative stress, leading to low uterine receptivity (Campo et al., 2012, Vannuccini et al., 2017).