CD4 and neoplasm: In our study, compared with the CDDP group, combining with Akk treatment suppressed the expression of CD4+CD25+Foxp3+ Treg in the peripheral blood and spleen, but combining with ABx treatment accelerated the expression of CD4+CD25+Foxp3+ Treg, suggesting that Akk could regulate the immune inflammatory microenvironment in the reversion of tumor growth and tumor immune escape.