TNF and neoplasm: Our findings indicated Akk combining with CDDP slowed down the growth of tumor volume and improved the changes of tumor pathomorphology, downregulated the levels of ki-67, p53, and FasL proteins and upregulated Fas proteins, induced the proinflammatory factor levels such as IFN-γ, IL-6, and TNF-α, and suppressed the expression of CD4+CD25+Foxp3+ Treg.