Interestingly, Routy et al. revealed that oral supplementation with Akk after fecal microbiota transplantation from cancerous person who nonresponded to ICIs repaired the blockage effectiveness of PD-1 in an IL-12-dependent manner by adding the recruitment of CCR9(+)CXCR3(+)CD4(+) T lymphocytes into mouse tumor beds [13]. This evidence concerns the gene CD4 and neoplasm.