INS and Hyperglycemia: MNCV was not different between groups (P = 0.8; Figure 4(d); control: 34.7 ± 5.1; STZ-DIO vehicle: 33.4 ± 5.5; STZ-DIO low-insulin: 32.8 ± 5.1; STZ-DIO high-insulin: 33.6 ± 7.4 m/s), suggesting no large nerve fiber damage after 16 weeks of hyperglycemia.