On the opposite side, results of a meta-analysis conducted by Shi et al. [42] indicated that nCD64 expression alone in the diagnosis of neonatal sepsis should be treated with caution, and it is not a satisfactory marker for diagnosing neonatal sepsis with relatively low sensitivity and specificity despite relatively high ROC area, and it should be combined with the conventional hematological sepsis parameters or CRP to increase its diagnostic efficacy. This evidence concerns the gene CRP and Neonatal sepsis.