CD4 and Cryptococcal meningitis: The Eswatini Ministry of Health revised its HIV guidelines in 2018 and included CrAg screening for adults with CD4 cell < 100 cells/mm3 or children with CD4 counts at less than 25% of total lymphocytes,12 as well as pre-emptive treatment as a package for advanced disease management to reduce morbity and mortality.26,27,28 Education of patients is important in order to inform them that cryptococcal meningitis is not, as some Swazi patients refer to it, the ‘headache that kills’, but rather a preventable and treatable disease (personal communication with patients).