However, imperatorin could not suppress the ability of CREB1‐knockout cells to form tumor metastasis, and more importantly, the anti‐metastatic effect of imperatorin was recovered when the cells were re‐overexpressed with wild‐type CREB1, but not the mutant CREB1 (Figure 6H; Figure S6, Supporting Information). Here, CREB1 is linked to neoplasm.