For example, imperatorin has been reported as a potential chemotherapeutic agent in human larynx cancer.[24] Another study showed that imperatorin could suppress drug‐resistant liver cancer through inducing Mcl‐1 degradation to cooperatively trigger Bax translocation and Bak activation.[12] However, most of the studies focus on the function of imperatorin in chemoresistance, we provide the first evidence suggesting the potential of imperatorin in suppressing tumor invasion and metastasis. Here, BAK1 is linked to liver cancer.