TMEM216 and aortic stenosis: Together with left ventricular hypertrophy, such a cardiac phenotype indicates aortic stenosis, a cardiac abnormality commonly seen in patients with Joubert syndrome.[53] Of note is that many cELV proteins directly or indirectly interacted with each other and TMEM216, a gene responsible for Joubert syndrome and Meckel–Gruber syndrome ciliopathy disorders.[3, 4, 5] The aortic stenosis may thus explain the drop in blood pressure.[54, 55] Overall, we here provide the first plausible explanation for primary cilia as antennae for cell–cell communication.