Although some variation and severity were observed, knockdown of the corresponding six genes (BMPR2A, BMPR2B, TFRC, F11R, PTPRS, and PGRMC2) resulted predominantly in ciliopathic disorders, including abnormal development, hydrocephalus, kidney cysts, and left–right asymmetry in cardiac looping (Movies S9 and S10, Supporting Information). This evidence concerns the gene PGRMC2 and Hydrocephalus.