Abbreviations: PD: Parkinson's disease; mTORC1/S6K1 pathway: mechanistic target of rapamycin complex 1/ribosomal protein kinase 1 pathway; FOXO1/HMOX1: forkhead box protein O1/heme oxygenase 1; IDE: insulin-degrading enzyme. Here, RPS6KB1 is linked to Parkinson disease.