COTL1 and neoplasm: Most of these genes, including SREBF1 (Audet-Walsh et al., 2018), CALM1 (Fortney et al., 2015), PCBP1 (Zhang et al., 2015), COTL1 (Guo et al., 2017) and BTK (Yue et al., 2017), are tumor-related genes, which have been reported to be associated with tumorigenesis, progression and therapy.