They were also closely related to tumorigenesis, such as MUC15 (Huang et al., 2009), HEPACAM2 (Klopfleisch et al., 2010), CA10 (Romeo et al., 2009), NRG1 (Huang et al., 2004) and RAB25 (Mitra, Cheng & Mills, 2012), providing a novel information layer to our understanding of ccRCC. This evidence concerns the gene CA10 and nonpapillary renal cell carcinoma.