In the streptozotocin-induced diabetic mice, knockdown of RAGE gene significantly improved electrophysiological and anatomical markers of diabetic neuropathy [112] as well as restored pain perception in sciatic nerves [117], in parallel with a decreased expression of NF-κB in peripheral nerves [117], and particularly in Schwann cells [112]. Here, NFKB1 is linked to diabetic neuropathy.