PRKAA1 and diabetes mellitus: In addition, a recent study revealed that AdipoRon administration ameliorates diabetes-induced glomerular endothelial cell and podocyte injury in db/db mice by activating the intracellular CaMKKβ (Ca2+/calmodulin-dependent protein kinase kinase-β)/LKB1 (liver kinase B1)-AMPK/PPARα pathway [18], suggesting an effective therapeutic strategy for treating DN.