However, another study suggested that resveratrol-related SIRT-1 activation alleviates cerebral ischemia reperfusion injury by inhibiting proinflammatory cytokine, reducing oxidative stress and apoptosis, and may protect against AD by inhibiting amyloid-β fibril formation, antiamyloidogenic effect, and delaying cognitive decline [12]. Here, SIRT1 is linked to Cerebral ischemia.