A higher baseline TAS (HR = 0.041, 95%CI = 0.008–0.218, p < 0.001), higher baseline SOD levels (HR = 0.983, 95%CI = 0.971–0.994, p = 0.004), higher baseline MDA levels (HR = 1.013, 95%CI = 1.001–1.016, p = 0.003), and females (HR = 2.228, 95%CI = 1.013–4.897, p = 0.046) were associated with glaucoma progression as measured by VF in a multivariate Cox analysis after adjusting for age, gender, BMI, SBP, DBP, smoking (yes/no), drinking (yes/no), the number of topical glaucoma medications, IOP, VCDR, CCT, AL, and ACD. This evidence concerns the gene SOD1 and glaucoma.