CASP3 and neoplasm: The antitumor effect of GQN is mediated its ability to regulate of the mitochondrial apoptosis pathway and inhibit tumor angiogenesis, that is, increasing the proapoptotic factors Bax, Cyt-C, and Caspase 3 and decreasing the antiapoptotic factor Bcl-2, as well as downregulating the angiogenic factor VEGF and decreasing MVD.