Therefore, this study was designed to observe the effect of GQN on the growth of HCC by establishing an H22 tumor-bearing mouse model and to reveal the effects of GQN on apoptosis and tumor angiogenesis by measuring the expression of the apoptosis-related proteins and genes Bax, Bcl-2, Cyt-C, and cleaved Caspase 3 (or Caspase 3) and by determining the tumor microvessel density (MVD) and expression of vascular endothelial growth factor (VEGF), which are key indicators of tumor angiogenesis [24–26]. This evidence concerns the gene CASP3 and hepatocellular carcinoma.