The antitumor angiogenesis of GQN should primarily be attributed to the main medicinal materials of Eupolyphaga steleophage, Hedyotis diffusa, Hirudo, and Scutellaria barbata in the formula because chemical components from these medicines, such as fibrinolytic protein [39], 4-vinylphenol [40], hirudin [41], and polysaccharide [42], can significantly inhibit tumor growth by downregulating the expression of VEGF or have significant antiangiogenesis effects. Here, VEGFA is linked to neoplasm.