Table S4), especially involved in p53 signaling pathway, ErbB signaling pathway, Regulation of actin cytoskeleton, MAPK signaling pathway, PPAR signaling pathway VEGF signaling pathway, Pathways in cancer and Toll-like receptor signaling pathway (Fig. 5b), which were ranked in the top 20 and were closely related to the cancer development. Here, TP53 is linked to cancer.