We found significant correlations between MRproADM serum concentrations and markers of renal dysfunction (e.g., cystatin C, r = 0.757, p < 0.001), reduced hepatic function (e.g., albumin r = −0.456, p < 0.001; pseudocholinesterase r = −0.499, p < 0.001; and prothrombin time r = −0.272, p < 0.001), and heart failure (e.g., N-terminal pro-B-type natriuretic peptide (NT-proBNP), r = 0.602, p < 0.001). The gene discussed is CST3; the disease is Abnormal renal physiology.