Pearson correlation analysis indicated that the serum CML levels were correlated with the area of colocalization of CD68 and ACTA2 (Figure 1(d)), and western blotting showed that the expression of RAGE in vascular samples from patients with diabetic foot amputation was higher than that in the control group (Figure 1(e)). Here, ACTA2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.