A considerable amount of studies in secondary models of hypertension indicate that reducing ROS production with Nox1/4 inhibitor GKT137831 attenuates hypertensive cardiac hypertrophy in rats subjected to abdominal artery constriction and angiotensin II-infused mice with cardiac-specific human Nox4 transgenic mice [5, 10]. This evidence concerns the gene NOX4 and Hypertension.