Therefore, it is of interest to document the molecular dockinganalysis data of the cellular receptor Glucose regulated protein 78 (GRP78) with Withaferin A from Withania somnifera in the context of COVID-19 pandemic for further consideration.Here, we report the optimal interaction features of withaferin A, artemisinin, curcumin and andrographolide with the GRP78 receptor having low binding energies (-8.7, -7.89, -6.21 and-6.17 kcal/mol respectively) in this report. The gene discussed is HSPA5; the disease is COVID-19.