β-cateninencoding genes like (CTNNB1), frizzled 10 (FZD10), T-cell factors 3 and 4 (TCF3/4) (TCF7L1/2), axis inhibitor 2 (AXIN2), and APC membrane recruitment protein1 (AMER1, WTX or FAM123B) arealso altered repeatedly in colorectal cancer [4]. The gene discussed is AMER1; the disease is colorectal cancer.