IRF1 and melanoma: Only the module turquoise had a significant enrichment (p = 0.009) of genes whose homologs displayed prognostic value in melanoma, such as Oca2, Samhd1, Nlrc5, Irf1, Ifitm3, Sp100, Dram1, Rtn1, Tcaf2, Parp10, and Grin3a (Fig. 2a and b).