MTF2 (metal regulatory transcription factor 2), for example, was shown to induce EMT by transcriptionally activating Snail in hepatocellular carcinoma, whereas PHF8 (PHD finger protein 8) is an enzyme that demethylates the H3K9, H3K27, and H4K20 lysine residues [47]. Here, PHF8 is linked to hepatocellular carcinoma.