In the subnetwork related to tumor progression (Fig. 1c), the hubs from the blue module are the most connected, such as the genes Cmas, Kmt2a, Golt1b, Cdc34, Manf, Sco1, and Thoc3, followed by hubs from the light cyan (Extl2, Commd3, Wdr41, Keap1, Osbpl9) and pink modules. The gene discussed is THOC3; the disease is neoplasm.