THEM4 and metastatic melanoma: In both analyses, the genes with the highest HR (depicted in red) were Plat, Ggh, Shc4, Them4, Nudt12, Rlbp1, and Hoxc13. SHC4 is expressed during the transition to metastatic melanoma [41], NUDT12 (Nudix-type motif 12) is a member of the NUDIX hydrolase family involved in cancer cell metabolism and survival [42], and GGH (γ-glutamyl hydrolase) regulates intracellular folate levels that are necessary for DNA replication.