SIRT6 and neoplasm: In contrast, histone modification genes from the blue and yellow modules (Fig. 5b) were more often upregulated in this cell line, such as Per1, Sirt6, Padi2, Mbd3, Suv39h1, and Kat8. MBD3 is a component of the NuRD complex that regulates epithelial–mesenchymal plasticity and tumor metastasis [48].