The impacts of AUDs among PLHIV include decreased help-seeking to HIV/AIDS care and treatment facilities [33], adherence problem to antiretroviral treatment (ART) drugs [3, 34–37], a decline of CD4 cells, increased load of the virus [36, 38], rapid HIV/AIDS disease progression and rising of opportunistic diseases [38–42], development of drug-resistant HIV strains [3, 36, 38], and finally contributes to premature death [43, 44]. The gene discussed is CD4; the disease is AIDS.