COL18A1 and non-small cell lung carcinoma: Although data from prospective phase III randomized control studies evaluating the efficacy and safety of endostatin combined with RT or CCRT for patients with LA-NSCLC are lacking, our pooled analysis indicates that endostatin combined with CCRT or RT presents a promising treatment modality in treatment of LA-NSCLC; subgroups of ECRT and ERT have similar efficacy and survival benefit, but patients in the ERT subgroup had lower rates of toxicity.